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FIGURE 10-33 Light microscopy of the renal lesion of preeclampsia: glomerular endotheliosis. On light microscopy, the glomeruli from preeclamptic women are characterized by swelling of the endothelial and mesangial cells. This swelling results in obliteration of the capillary lumina, giving the appearance of a bloodless glomerulus. On occasion, the mesangium, severely affected, may expand. Thrombosis and fibrinlike material and foam cells may be present, and epithelial crescents have been described in rare instances [2].
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Angst, J., Bente, D., Berner, P., Heimann, H., Helmehen, H. & Hippius, H. 1971 ; Pharmacopsychiatry 4, 201-211. Stillej G. & Hippiuis, H. 1971 ; Pharmacopsychiatry 4, 182191. Beer, B., Chasin, At., Clody, D. E., Vogel, J. R. & Horvitz, Z. P. Science 176, 428-430. Harris, J. E. & Baldessarini, R. J. 1973 ; Neuropharmacology 12, 669-679. And6n, N.-E., Roos, B. E. & Werdinius, B. 1964 ; Life Sci. 3, 149-158. Bernheimer, H. & Hornykiewicz, 0. 1965 ; Arch. Exp. Pathol. Pharmacol. 251, 135. Bell, B. T., Viek, P. & Santangelo, S. C. 1960 ; J. Amer. Med. Ass. 174, 1976-1977.
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Is shown in Figs. 2A, 2B and 2C, respectively. In non-tumor tissues, strong signals were observed only in the lymph follicles Fig. 2D ; . The intensity of lymphoid follicles was 2 moderate ; . The intensity and extent % positive area ; of COX-2 staining in each cancer grade are summarized in Table 2. In order to investigate the relationship between COX-2 expression and cancer grade, the COX-2 scores were next evaluated in the bladder tumor specimens Fig. 3 ; . The mean value of the COX-2 score in each grade was as follows: grade 1, 3.25 1.96; grade 2, 4.41 1.58; and grade 3, 4.93 1.97. The score was higher in the high grade cases with a significant difference between grades 1 and 2 p 0.05 ; and grades 1 and 3 p 0.01 ; . Additionally, we evaluated the relationship between COX-2 expression and tumor stage Fig. 4 ; . The mean value of the COX-2 score in low and high stage was 1.65 0.13 and 2.24 0.20, respectively. The.
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Developing or improving chemical products and processes to make them less hazardous. In 1991, OPPT launched a model program that for the first time provided grants for research projects that included pollution prevention in the synthesis of chemicals. Since then, the EPA Green Chemistry Program : epa.gov greenchemistry ; has built collaborations with academia, industry, other government agencies, and nongovernmental organizations to promote pollution prevention through green chemistry. Green Chemistry at Work Chemical manufacturing is the source of many useful products. These include antibiotics and other medicines, plastics, gasoline and other fuels, agricultural chemicals such as fertilizers and pesticides, and synthetic fabrics like nylon, rayon, and polyester. These products are important but some of the chemicals and processes used to make them harm the environment and human health. Green chemistry aims to reduce pollution by preventing its creation in the first place. In designing a chemical reaction according to the principles of this discipline, chemists pay close attention to what is known about possible hazards a chemical presents to health or the environment before using the chemical in a reaction or creating it as a product. In other words, they treat the hazard a substance poses as a property that must be considered along with other chemical and physical properties and select substances that minimize harm. In their 1998 book, Green Chemistry: Theory and Practice Oxford University Press ; , Paul Anastas and John Warner developed 12 principles that give chemists a road map for implementing green chemistry. Four of the principles follow. 1. Get off to a safe start: Identify reactions that use nonhazardous starting materials to make a desired product. This minimizes danger to workers in manufacturing plants when they handle chemicals and prevents accidental release of harmful chemicals from leaks or explosions. A new way to make an important industrial chemical, adipic acid, illustrates this principle. Almost 2 billion kilograms of adipic acid are needed each year to make nylon, polyurethane, lubricants, and plasticizers. The standard way to make adipic acid uses.
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